Epithalon (Epitalon)
Epithalon is a research peptide consisting of a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the natural thymic peptide Epithalamin. It has been shown in preclinical research to influence telomerase activation, oxidative regulation, and circadian gene expression via modulation of pineal peptide signaling pathways. Epithalon is utilized as a model compound in studies investigating genomic stability, epigenetic control, and neuroendocrine peptide regulation.
References:
Khavinson VK et al., Bull Exp Biol Med, 2003;135(4):429–432
Khavinson VK et al., Biogerontology, 2007;8(3):305–313
Anisimov VN et al., Neuro Endocrinol Lett, 2003;24(3–4):233–240
Anti-Aging & Longevity
May help maintain telomeres, slowing cellular aging processes.
Research studies have shown increased lifespan and improved organ function.
Sleep & Circadian Rhythm
Epithalon may normalize melatonin secretion, improving sleep quality and regulation of sleep-wake cycles — especially in older individuals whose melatonin drops with age.
Better sleep supports mood, metabolic health, and immune function.
Neuroprotection & Cognitive Support
Animal and cellular studies suggest possible protective effects on brain cells and support for memory and learning.
May help reduce oxidative stress in neuronal tissues.
Immune System & Oxidative Stress
Some research indicates immune modulation, potentially improving T-cell function and reducing age-related immune decline.
Epithalon may also act as an antioxidant, lowering free-radical damage.
Skin, Tissue Health & Repair
Better cellular repair mechanisms may support skin elasticity and tissue maintenance, though direct clinical evidence in humans is limited.
Metabolic & Hormonal Effects
Studies suggest potential benefits for hormonal balance, including regulation of melatonin and possibly other endocrine signals.
Preliminary animal data hint at improved glucose metabolism and insulin sensitivity.
