Kisspeptin-10 is a synthetic decapeptide (Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂) corresponding to the active fragment of the KISS1 gene product. It binds to the GPR54 (KISS1R) receptor, activating Gq-mediated signaling cascades and modulating gonadotropin-releasing hormone (GnRH) expression in preclinical studies. Kisspeptin-10 serves as a tool for exploring reproductive and neuroendocrine peptide signaling.
 
References: 
Kotani M et al., J Biol Chem, 2001 276(37):34631–34636
Oakley AE et al., Endocr Rev, 2009 30(6):713–743
de Roux N et al., N Engl J Med, 2003 349(17):1614–1627
 
Overview:
Kisspeptin-10 is a naturally occurring peptide that has garnered significant attention in reproductive biology. As a critical regulator of the hypothalamic-pituitary-gonadal (HPG) axis, it plays an essential role in reproductive function. Originally discovered for its role in cancer metastasis, its influence on the reproductive system has become the focus of extensive research.
Key Functions and Benefits:
Fertility and Reproductive Health: Studies indicate that Kisspeptin-10 is crucial for maintaining fertility. It regulates the menstrual cycle and ovulation in females and supports spermatogenesis in males.
Regulation of Puberty: Kisspeptin-10 is vital for the initiation of puberty, triggering the release of GnRH, which leads to the production of sex hormones and the development of secondary sexual characteristics.
Potential Therapeutic Applications: Ongoing research explores the potential therapeutic uses of Kisspeptin-10 in treating reproductive disorders such as hypogonadotropic hypogonadism, polycystic ovary syndrome (PCOS), and infertility.
Hormonal Regulation: By influencing the HPG axis, Kisspeptin-10 helps maintain hormonal balance, impacting mood, energy levels, and overall well-being.