Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from the ACTH(4-10) fragment. It is widely utilized in research investigating neurotrophic and nootropic signaling via modulation of BDNF, TrkB, and neurogenic transcription factors such as NGF and GAP-43. Experimental data indicate its capacity to affect redox balance, neuronal plasticity, and dopaminergic regulation in central nervous system models.
 
References: 
Ashmarin IP et al., Neurosci Behav Physiol, 1998 28(3):341-348 
Ashmarin IP et al., Neurochem J, 2005;39(1):36–44
Dolotov OV et al., Brain Res Bull, 2011 85(5):327-332
 
Overview:
Semax: Neuroprotective and Cognitive Peptide
Semax is a synthetic peptide that has been widely studied for its neuroprotective and nootropic properties. This heptapeptide is an analog of adrenocorticotropic hormone (ACTH) but lacks hormonal activity, making it a promising candidate for various neurological and cognitive research applications.
 
Mechanism of Action
Semax is believed to exert its effects by modulating the brain’s dopaminergic and serotonergic systems. It influences neurotrophins like brain-derived neurotrophic factor (BDNF) and promotes neurogenesis, synaptic plasticity, and neuronal repair. Additionally, Semax has been shown to regulate stress-response pathways and protect neurons from oxidative stress and ischemic damage.
 
Research Applications
Cognitive Enhancement: Improves learning, memory retention, and focus in various studies.
Neuroprotection: Demonstrates the ability to safeguard neurons in conditions such as stroke and neurodegenerative diseases.
Stroke Recovery: Studied for its role in aiding recovery from ischemic strokes by enhancing blood flow and neuroplasticity.
Stress and Anxiety Regulation: Exhibits anxiolytic properties and helps reduce stress-related behaviors.
Mood Improvement: Potentially supports mood regulation by affecting neurotransmitter pathways.
Pain Management: Investigated for its ability to reduce chronic pain and inflammation.
 
Key Benefits Noted in Research
Increased BDNF expression for enhanced neurogenesis and cognitive function.
Protection against oxidative stress and ischemic injuries.
Potential therapeutic applications in ADHD, anxiety, and depression.
May aid in recovery from traumatic brain injuries (TBI).
 
Molecular Profile
Molecular Formula: C37H51N9O10S
Molecular Weight: 813.92 g/mol